Facilitated

32| From Pixie-Dusted Pills To Proven Protocols: GLC 2025 Recap

• The Facility Denver • Episode 32

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We unpack a weekend of research into practical steps: food-first strategies, meaningful biomarkers, and supplements at real doses that move the needle. From omega-3 targets and nitric oxide to fiber, PFAS, mastic gum, tocotrienols, and saffron, we focus on what works and how to apply it.

• diagnosing biology before disease
• supplement quality versus "pixie dusting"
• habit formation before optimization
• balancing research for women and men
• homocysteine as a bone and methylation marker
• omega-3 index targets and SMASH fish
• nitric oxide, nasal breathing, and mouthwash risks
• PPIs, H2 blockers, and vascular health
• mastic gum for H. pylori protocols
• fiber goals, microbiome shifts, and oats
• beta glucan for cholesterol and PFAS support
• quercetin foods: capers and onions
• NAD support and mood formulas with saffron
• tocotrienols, GG, and triglycerides as early signal

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Stay curious, stay proactive, and we’ll catch you next time!

SPEAKER_01:

Welcome to Facilitated, where we bring you real stories, strategies, and science from the world of functional medicine. I'm Dr. Mitchell Rasmussen, a functional medicine practitioner.

SPEAKER_03:

And I'm Kate Darty, a certified nutritionist. We are the owners of the facility, a functional medicine clinic here in Denver, Colorado.

SPEAKER_01:

We help people improve their biology and get out of their own way. In my view, our work is about getting to know the person with the condition much more than it's about understanding which condition the person has. As I always say, diagnose the biology, not the disease.

SPEAKER_03:

On this podcast, we break down complex health topics, share real patient cases, anonymized, of course, and explore cutting-edge wellness strategies so you can make informed decisions about your health. Quick heads up before we dive in. This podcast is for education and general information only. We're here to share insights, not to diagnose or treat. So if you're dealing with a health issue, chat with a qualified healthcare provider before making any changes. All right. Okay.

SPEAKER_01:

Hello.

SPEAKER_03:

Back in the studio after another weekend away, weekend conference. This time I stayed here in Denver and Mitchell went to Minneapolis for the Great Lakes conference hosted by Neutrodyne.

SPEAKER_01:

I think it was the I think I've gone 12 of the last 13 years. I was thinking about it. The first one I went to was 2013. It's actually what led me to want to become a chiropractor was I was doing some uh movement training with uh random kids from my undergrad in Minneapolis, and one of them, a couple of them were chiropractic students, and they were like, Oh, you really love movement and nutrition, like you should become a chiropractor. I remember I was like, I am not becoming a chiropractor because all I thought of was cracking bones, cracking joints. And this one gal who became a friend of mine invited me to this thing, this Great Lakes conference, and I rolled my eyes, but uh I was open to it. I trusted her, she was cool. And I went and I learned Dr. Mark Houston, who worked at Vanderbilt Medical School at the time, he's an expert in all sorts of cardiovascular and things, and he was talking about the real causes of heart disease and how they're not because of a deficiency in things like statins. And what I realized was this system-based thinking called functional medicine was perfectly aligned with my desire to always ask why. Why, why, why? And I actually went home after that lecture, realizing that I could become a chiropractor and I could run all these tests and I could do this extra education. And I went home and I did my essay to apply to chiropractic school.

SPEAKER_03:

And here we are.

SPEAKER_01:

And here we are, 13 years later. Um, so yeah, I mean it's fun. I got to see some classmates from school. One of my uh he's become a friend of mine, an emergency room physician out of Salt Lake. I always get to see him, and that's always a good time. And I always leave very inspired. Yes. Text you all throughout the weekend.

SPEAKER_03:

Yes. And I've gotten to hear little bits of it in our patient visits this week. You were already bringing up some clinical pearls, and so now we'll get to kind of expand on new things you found interesting, what you want to dive deeper into, more research to be done, always more learning to do.

SPEAKER_01:

So yeah, I a lot of times seminars can uh just essentially become a sales presentation. What I really like about Great Lakes is yes, it's put on by a nutrition company, but they're big on uh helping people understand the application and the research behind why are why do our products maybe cost more? And it's because when you look at actual human data, a lot of products that are made are pixie dusted. Right? They have tell us what that means. Well, you know, you put a lot of fancy names on a label, but whereas an efficacious dose of something might be three to five hundred milligrams, they might put five or twenty-five. So you can say, hey, includes berberine. And we just had this come up with a patient who found this sexy product called IM8, right? All this amazing marketing, and there was like she asked me what I thought about it, and it was like, well, this proprietary formula at the end that says it has all these blood sugar balancing things is 25 milligrams. And if I give someone berberine, I'm giving a thousand milligrams a day or fifteen hundred. So twenty-five is not it's pixie dusting. Yeah, so you get what you pay for.

SPEAKER_03:

If you listen last week, you learned about health health halos, and now we've got pixie dusting.

SPEAKER_01:

Um, and that's where uh all supplements are not created equal without having FDA uh clearance for supplements. You need to really go to a uh company that does the legwork, pays the extra money to be tested, have their products tested, have their raw materials tested, and then have pharmaceutical grade uh manufacturing processes that keep what you don't want out and make sure that what the label says is what's in it. So, anyway, obviously I love Neutrodyne. You know, they're really you know family company, but what I really love about them is they're not rushing products to market, they take their time. Very similar to us with WellPros that we developed, they don't want to be first on the market, they want to be best on the market. And they're new, they're releasing three new products this year, and that's typical for them. And one of them I learned so much about this NAD enhancing oral supplement and went through all the data between all these and different ingredients, and another example where some of these other products on the market with sexy marketing do not have efficacious dosing of things like nicotinamide ribicide. You know, and in this product is I'm excited to try it with our clients, but also myself, because you know I like to experiment. And you know, and that's what it's all about is learning the data and the science and the application, and then understanding how the products fit in, and that's what they do so well.

unknown:

Nice.

SPEAKER_03:

All right, well, there's one quote that I've heard I don't know, probably ten times with clients this week. Yeah.

SPEAKER_01:

So go ahead, let's see if you memorize it.

SPEAKER_03:

No way. Something about you have to establish a habit before you optimize a habit.

SPEAKER_01:

Yeah. And pull on a few strings in the system in the web and the system will rebalance and then make a few others.

SPEAKER_03:

So the application of that is let's say something is basic as strength training. You need to establish the habit of going to the gym on a regular basis before you start to optimize exactly what the programming is.

SPEAKER_01:

Yeah, I mean, we did that with somebody today. I asked, can you do 15 minutes at home once a week with a YouTube video that resonates with you? Of course, in six months, I want you exercising four hours a week. Right.

SPEAKER_03:

With nutrition, it might be can we get you eating adequate calories before we think about what your macronutrient ratios are?

SPEAKER_01:

Yeah.

SPEAKER_03:

Can we how much fiber are you consuming?

SPEAKER_01:

Can we get you to turn the phone off at night and go to bed before we ask you to get a whoop strap and tell me how long you're how many REM cycles you went through. Sure. Which by the way, anybody who's listened to me for any amount of time knows that I'm not a big fan of any wearables. So I digress. Um the first lecture on Saturday morning was with uh medical doctor, Dr. Board. Um she started as an anesthesiologist and a pain doctor, and then uh over the last couple decades has transitioned into personalized lifestyle medicine, and it was great. She started, she talked a lot about bone health, and then her entire second half was all about men. And something that she said was in the last couple of decades, this push to get more studies on women has actually led to there being about 10 to 15 times more studies looking at women than men over the last few years. And I think the pendulum will swing side to side. And uh, I've been saying for years, I go to these certain lectures, and I've heard things like, well, men don't need help with their mental health, they're fine, women need the support. I believe that who needs support are people. I don't look at it as such a binary way of like, well, men need more help or women. People need help, people need community, people need guidance, people need support. Uh let's swing that pendulum to the middle where we can look at all humans should not have to suffer through their health issues. So I appreciated that she was really focused on uh let's look at everybody.

SPEAKER_03:

I mean, I will put play a little bit of advocate in that I really think as Stacy Sims says it all the time, women are not small men. Right. So we can't take the men's studies and apply them to women. Same thing we can't apply the women's studies to men. So there needs to be both, but sure, more balance to the research.

SPEAKER_01:

And you hear me say that to women all the time who want to go do the HIT classes in an altitude room with their husbands when they're about to ovulate. Or let's say they ovulated 10 days ago and you know they're uh in maybe a weird part of their luteal phase and not feeling super rambunctious. You are not a small man. But um, one thing we measure everybody's homocysteine, it's an inflammatory marker, speaks to how well you're methylating, it has a big impact is made upon it with B vitamin status, and we look at it as a generalized inflammatory marker, and Dr. Board talked so much about with bone density that uh post-menopausal women with a higher homocysteine are it's completely related to lower bone density. So I'm just thinking about other applications for that marker that's ten dollars that we run on everybody. Um, and then I also learned about a couple new tests for prostate screenings, which I'm excited about, but I don't know if that's the scope of today. If you're concerned about your prostate, look into the 4K score.

SPEAKER_03:

4K score.

SPEAKER_01:

Dr. Chad Oler talked a lot about endothelial dysfunction, which I think I've recorded a podcast on. It was that with you know metabolic syndrome and heart disease and things, but uh he talked so much about omega-3 status, and that's a test we regularly run on our clients, is an omega-3 index, where we can actually uh take a small sample of your blood, send it to a lab, and they will analyze the membranes of your red blood cells in order to see the different types of fats within that membrane. And we now I now have a little more information looking at a one stat that he said was if we can get your omega-3 index above eight percent, it's associated with a 90% reduction in sudden cardiac death. Which eight percent takes work. Yeah, you saw our lunch today. You and me in April, we all had a can of sardines.

SPEAKER_03:

April and I had mackerel, but yeah, we had 10 fish.

SPEAKER_01:

Okay, I had the poor man's mackerel.

SPEAKER_03:

Which segue, we had a patient ask us this week. Is it better to consume your omega-3s from fish or from supplementation?

SPEAKER_01:

Food first, baby. Yeah, always. Yeah, I always looking at food first, but and it's all about the ratio. You know, I'm you know, I weigh about 210 pounds, so I eat around 100 grams of fat a day, so 700 grams of fat a week. And if I'm trying to get the balance between my sixes and my threes, I'm probably getting about you know 30 grams of omega-6 fats a day from eggs and chicken and even some of the meats I eat. And then go to a restaurant, have some chips, you know, and I don't sweat those things, but I need to get that balance so that 8% of my cell membranes are coming from omega-3s. That takes a lot of effort in my diet and supplementation. If you're eating, you know, someone like you, you're probably getting around 60 grams of fat a day. It's a lot easier, a lot more realistic for you to get that from fish. Um, we know that the phospholipid form, especially in we talk about this with pregnancy, like roe, salmon roe. They're that DHA in that is so easily used by the brain because it's in that phospholipid form, and a lot of supplements are in that ethylester form, so they're just not quite as effective at being integrated into cell membranes, but still effective. You know, he even said we can get your omega index. Again, we want a number like eight to twelve percent. I say ten. If you have an omega index of four, which is pretty typical for what we see, you need to increase your EPA and DHA about a gram and a half per day, and it takes five months to go from four percent to eight percent.

SPEAKER_03:

Oh wow.

SPEAKER_01:

So it takes a little bit of time, but it also can be doubled in that time if you really focus on it. So inclusion, Kate. You talk so much about that with the people we work with, right?

SPEAKER_03:

But it's it's inclusion, but it's naturally exclusion. So if you replace three meals a week with fish instead of chicken or beef, you're both increasing your omega-3s and reducing the amount of omega-6 you're you're consuming by that replacement.

SPEAKER_01:

And if you just take a supplement, you've got room in your tummy.

SPEAKER_03:

You're probably still eating those higher omega-6 meals.

SPEAKER_01:

So, how I how I manage that personally is I take I use the pro-resolving mediator form of fish oil, it's just better. It just is. There's enough data now to show that pro-resolving mediators are optimal forms of fish oil. I mean, within those, I take 1.8 grams a day, and then I eat fish about four times a week. I'm pretty diligent with it, and that that it takes that to keep my omega index above eight percent. You know, it's so I I don't think at this point, unless there's an allergy, I don't think we've got any excuse to avoid fish.

SPEAKER_03:

Smash fish, but yeah, so it's gonna that was gonna go in there. Salmon, mackerel, anchovies, sardines, herring, smash. It's an acronym, lowest in can contaminants. So thinking about heavy metals, PCBs, but also highest in omega-3s.

SPEAKER_01:

Yep, and then even like shellfish if they're wild caught, but not a lot of fat in those. So looking for more like minerals and protein. Um, Dr. Oler, within that conversation around endothelial dysfunction, spent probably 45 minutes talking about nitric oxide, and something that we're very familiar with. Why we want to hold and exhale when we're breathing and then inhale through the nose. You know, our sinus cavity has these nitric acid, uh, nitric oxide synthesizing cells. When you breathe through the nose, you pull those uh mediators into the lung beds where they can diffuse nitric oxide into your capillaries. So that's interesting. But he was talking a lot about the nitrate-reducing oral bacteria, and we we talk about this with patients a lot things like chlorhexidine, mouthwash, hydrogen peroxide. Uh, we know that they kill a lot of these nitrate-reducing bacteria, but he really reinforced that for me that we've got to continue asking the people we work with about that, especially if they're dealing with uh well, normal people stuff, fatigue, brain fog, dizziness upon standing, but even blood pressure.

SPEAKER_03:

Erectile dysfunction.

SPEAKER_01:

Exactly. That was a big part of uh with Dr. Board talking about men transitioning to Dr. Oler talking about endothelial dysfunction, it's uh a massive complaint for men is erectile dysfunction, and controlling for the vasodilatory effects of nitric oxide is a must. And when it comes to hypertension, until you've improved your nitric oxide uh production in your body, that will be the cause of your essential hypertension until you've proven otherwise and optimized that. And it's easy. You can do, you know, nutridyne even offers nitric oxide testing strips if you want to see the impacts of where you're at and then what a big meal of beets or arugula does for you. And that's actually what I appreciated about this weekend so much. You know, Dr. Oler is a naturopath, you know, he's there on behalf of Nutridyne. Half of his time was spent talking about food, which I thought was amazing. Like, thank you for not just telling me the only way I can get it is through supplements. Like it was a very real, relatable talk that we had. Um, he mentioned that uh some studies are now showing if you take proton pump inhibitors for acid for three to five years.

SPEAKER_03:

So that's things like omeprazol, pantoprazole, those heartburn medications.

SPEAKER_01:

There's a 35 to 40 percent incidence of heart attack and stroke due to poor nitric oxide production within the gut. Because you need stomach acid. Um, I tell everyone to hum. He now gave me a stat I can hold on to. Humming can increase NO production by 15 times.

SPEAKER_03:

Immediately? How long it would take. Yeah, very quickly.

SPEAKER_01:

I don't know how long it lasts. Nitric oxide only lasts in the blood like half a second. So you're constantly having to recycle and re-produce. Humming all day long. Yeah, yeah. Create another thing for me to do. Yeah, and he mentioned that uh for you know distracting. We've got yeah, it is. We've got some clients with Barrett's esophagus, and he even said for them, if you can work with their prescribers to get something like Xantac instead of a PPI, like uh working on those H2 pumps can be a little bit better as far as bone density goes, um, and also nitric oxide production.

SPEAKER_03:

And that's significant because those patients with Barrett esophagus are expected to be on those PPI medications over a long term. So using something like an H2 blocker, agonist blocker.

SPEAKER_01:

We'll just go with whatever you want to say.

SPEAKER_03:

Okay. Using the alternative medication is significant over the long term.

SPEAKER_01:

Yeah, exactly. And I was reinforced, you know, I ask a lot of questions, and these you don't ask them directly, you put them into a thread, and then at the end of each day, all of the doctors that presented will sit up on the stage and go through them.

SPEAKER_00:

Okay.

SPEAKER_01:

And I got a nice uh reinforcement about using mastic gum when we see H. pylori. We've been pretty bullish on the idea that we don't need to run to prescription antibiotics for H. pylori for the most part. We can use things like SBIs, you know, bovine immunoglobulins. Um, but he talked a lot about yes, it's going to take a little bit longer, but things like mastic gum are highly effective at eradicating H. pylori, and you don't get all the side effects. Right. So that was reinforcing for me. Dr. Mayfield Sunday morning.

SPEAKER_03:

Dr. Rick Mayfield.

SPEAKER_01:

Yep. My favorite. I look forward to his talks every year. He's the chief science advisor for Neutrodyne. He's also the product developer or the lead, and he's obsessed with olive oil. Every year we get more and more. And I got actually his resource, which I'm gonna try to get an account with. It's a European company.

SPEAKER_03:

Yeah, but tell us what the company is.

SPEAKER_01:

Oliveoilovers.com.

SPEAKER_03:

Oliveoilovers.com.

SPEAKER_01:

Maybe there will be an affiliate code in these notes if we can get it in time.

SPEAKER_03:

Just something about it makes me like not want to go all in. I wish they had a different a different name.

SPEAKER_01:

It's also hard to type when you read the olive oil lovers. A lot of L's, you know. But hey, if you're looking for a healthy olive oil from Crete or Italy or Spain or Greece, look there. Um, but he you know, he always talks so much about the gut microbiome. Uh got into longevity quite a bit. That's the hot topic now, but he approaches it from you know, it's not get the peptides and plasmaphares, it's like relatable things like can I improve my fecalobacterium prosnitia?

SPEAKER_03:

Oh, so relatable.

SPEAKER_01:

Right. Down to earth. Um and all I wrote was need to read more about it. It's something we test on our stool tests.

SPEAKER_03:

Yeah, we know it's a beneficial bacteria, and more of it likely has a benefit. Relatable.

SPEAKER_01:

Yeah, right, exactly. But like, and how do we do that? I mean, a lot of times it's through fiber supplementation. He spent a lot of time discussing how the fiber recommendations are probably way too low in the United States, and he referenced a really interesting study where they took groups of uh black Americans and then Africans eating traditional Western diet on you know, black Americans, prescribing and keeping the traditional African-style diet, which was about between 50 and 120 grams of fiber a day, and there was repeat stool tests on these on these populations. They swapped the two groups for like I think 12 weeks. And the standard American, they were eating about 12 grams of fiber a day. Burgers and you know, typical American food. And what they saw was these the the gut microbiomes shifted drastically just within 12 weeks for each group, and then certain risk factors for colon cancer, polyps, things like that got worse, inflammation in the colon, and then switching them back, the microbiomes readapted. So this is this is not you are not your history in that way. You can change this, and you should change this. And he thinks we likely men need to probably get more than more like 50 grams of fiber per day. And he kind of joked, like, okay, you have a 140-pound woman, 140-pound man, why would a man need 38 grams of fiber and a woman need 25? You know, it should be more based on you know calories. Calories, yeah.

SPEAKER_03:

Yeah, I think I talked about that a little bit in my fiber episode.

SPEAKER_01:

But I'm even, you know, and sometimes I get because I've started tracking it, I get like 65 grams of fiber per day, and I'll sometimes be like, Well, I feel fine, but maybe this is a bad idea. Nah, now I'm excited about it. Yeah. So really pushing that fiber. You talked a lot about forever chemicals, PFOS, and one thing, and I looked it up because I was like, There's no way that that's accurate. And it would, I mean, everything I found supported what he said. Looking at uh just having three grams of oat beta glucan soluble fiber a day, these PFOS will significantly decrease in concentration in the body. We also know that oat beta glucan reduces cholesterol because it enhances bio acid elimination. So I don't agree with people like I love I actually like Dave Asprey.

SPEAKER_03:

Me too.

SPEAKER_01:

You know, I appreciate his a plum and sharp guy, not you know, nobody's right about everything, but he kind of talks S about oats.

SPEAKER_00:

Yeah.

SPEAKER_01:

I like oats. Yeah, peasant food, and like it's like look, get them sprouted, get make sure they're glyphosate free, keep them mold free by storing them properly. Man, great for cholesterol. And now that I'm looking at the study on uh forever chemicals, we're exposed to these things constantly through cookware and food takeout containers and all sorts of exposures, and knowing now that a small dose, three grams, can significantly decrease PFOS in the body, I think we've really got to be open to this peasant food.

SPEAKER_03:

I agree. Do you know how that three grams of beta glucan translate to whole oat?

SPEAKER_01:

Well, the amount of oats I eat a day, I think, is 10 grams of fiber. And so oat beta glucan is soluble. I would have to look at the label, but I don't think it's that hard to get three.

SPEAKER_03:

Okay. So you could make your oatmeal in a plastic bowl.

SPEAKER_01:

Retox to detox. That's my kind of girl, yeah. Um and what's interesting is bio acids are very chemically similar to these PFOS. They're both amphipathic, they have a very similar pH, similar molecular weights. So we're just gonna glance over that one. Okay, fine.

SPEAKER_03:

Ampath Amphipathic.

SPEAKER_01:

Amphipathic. They're not lipophilic or hydrophilic. Can you cut this out?

SPEAKER_03:

Yep.

SPEAKER_01:

This whole thing. Yep. Okay. We're almost done.

SPEAKER_03:

I thought it was funny, so I left it.

SPEAKER_01:

Kate, I have a trivia question for you.

SPEAKER_03:

Okay, I'm pretty good at trivia.

SPEAKER_01:

What is the highest food source of quercetin?

SPEAKER_03:

You told me this and I already forgot it. And I was gonna it's not it's not onions. I want to say onions, and no, it's not onions. It's not garlic. It's something that I eat, but I can't remember.

SPEAKER_01:

That's mostly sits in the pantry. Capers.

SPEAKER_03:

That's right, you told me that.

SPEAKER_01:

Yeah, capers have the highest food source of quercetin, and you know, when we give the in the supplements a it's a polyphenol, uh, we'll typically give it like 500 milligrams at a time. But he talked about even from whole foods, if you get like four milligrams, it's cardioprotective. So again, an example where whole food is always best.

SPEAKER_03:

Okay, so highest concentration of quercetin, meaning not highest concentration not high highest per serving. So think about what a s a typical serving of capers is. It's like you might have a teaspoon of them.

SPEAKER_01:

I think it's per 100 grams.

SPEAKER_03:

Okay.

SPEAKER_01:

Is that a lot of capers?

SPEAKER_03:

A hundred grams of capers, yeah. Okay.

SPEAKER_01:

Gross. Okay, well, maybe just have a small red onion and buckwheat and cranberry then. Um last things. So two of the products that I'm really excited about are a new NAD supporting supplement, and he, you know, he broke down ingredient by ingredient, looking at human trials, looking not just at animal data like so many companies do, and just slowly built out over the course of like 45 minutes this product that they're developing that'll be out in the next couple of months that's helped to help support NAD that doesn't involve painful thousand dollar injections. And I'm very excited about that. You know, obviously it has you know nicotinamide riboside, but then has things like Rutin, which is a quercetin derivative, and a few other ingredients that are, again, all in these clinically relevant doses. That's cool. I'm excited about that. But I think more relevant for a lot of people we see is a product they're making called Uplift that has, again, based on the human data, that has I think seven different compounds, things like saffron, which have been shown to balance out mood, not have a ton of drug interactions, and very, very safe to take long term for individuals with anxiety and depression. He talked about a study, this was like back in the 90s, but these things get buried because there's no money in this. That studies have shown saffron has similar benefits for ADHD in children to Ritalin without the side effects. You know, methylphenidate or Ritalin is a central nervous system stimulant. It has all sorts of side effects on the cardiovascular system, especially. And again, this is information that's been around for a while that just gets buried for whatever reason. Take that with what you want. But I'm so excited about this uplift product. I'm gonna try it.

SPEAKER_03:

Yeah, I like how you said very little drug interactions because that makes me excited for patients who might be on SSRIs or ADHD medications and looking to transition off where they can start something like this as a bridge.

SPEAKER_01:

And that this has been a hole in the marketplace. I mean, right now for children, it's like, well, let's get off artificial colors and flavors, let's up the magnesium, let's up the fish, let's try neural feedback, things like that, get off the phones and things and exercise, you know, get these little kids running around. But it hasn't, you know, with a kid, I'm not gonna recommend something like methylene blue.

unknown:

Right.

SPEAKER_01:

Right? And especially if you're on a lot of medications, methylene blue is contraindicated. So it's it's this is a hole in the in the marketplace, if you will, for so many people. And I'm excited that they're now Lean into that with this new uplift product. L-theanine, really efficacious dose. I think 400 milligrams. I mean, again, a lot of these products, if you look at your labels, contains L-theanine, and it's like 50 or 100 milligrams. You know, the stuff that we use is it's always based on what will be most relevant to move the needle for these clients.

SPEAKER_03:

Okay, the last one you texted me about was Dr. Tan. Oh my gosh.

SPEAKER_01:

A gym.

SPEAKER_03:

His picture is adorable.

SPEAKER_01:

Yes, Dr. Barry Tan. He is uh the foremost uh world's foremost expert on tocotrienols, and he discovered tocotrienols in the annatto plant and his native, I think he's Malaysian. He's a PhD chemist, and his entire life's work is on tocotrienols and something called gerinol geraniol GG, and both of these products are within the innatto plant. We and we tell this to our clients all the time, and I'll keep this brief, but vitamin E, there's like eight different isoforms, and the synthetic ones are tocopherols that you'll see on your uh typical multivitamin like alpha tocopherol, and that might have some indications during pregnancy, but there's not uh, you know, it's an antioxidant vitamin E, but studies don't really show that alpha tecopherol helps improve longevity, improve heart disease risk. It just so then what the study what people will say is, oh, vitamin E doesn't work. Well, we've been using tocotrienols for years now. It was so crazy to meet the discoverer in person. Flew over here from he were he's got a lab in uh Massachusetts and spoke all about his life's work and just the passion he has, the studies they are conducting on humans. And uh, I guess what I took from it is for certain conditions, we need to get quite high doses of the tocotryenols. We know that antioxidants in the wrong dose can become prooxidant. So question that I posed was do you see any research at these four to six hundred milligrams of tocotrianols dosing causing a prooxidant effect? And he said, We have actually studied that a few times in large populations, and what we find is the prooxidant effects only happen with the tocopherols, not the tocotrienols. One thought is, or one thing we know is the tocopherols and tocotrinols compete for binding in the body, so don't take them within six hours of each other. But that's the recommendation we've been giving for years. But it was just I understand now more of the mechanism of binding that he went through of why that's relevant. Um for if if you're gonna be taking these tocotrienols. And the last little nugget that Dr. Tan gave was talks his so much of his research is on metabolic syndrome, hypertriglyceridemia, and he said that hypertriglyceridemia always precedes hyperglycemia. High fat is the gatekeeper until the floodgates burst, and then you will see hyperglycemia.

SPEAKER_03:

Yeah, and we see that all the time.

SPEAKER_01:

But I love the way he said it, it's the gatekeeper, it holds back the floodgates. So, and we when we whenever we see high triglycerides, the first thing we do is reduce the fructose and the processed sugar in someone's diet. But now just thinking about it is well, that is the normal response that your triglycerides will continue to go up, and then all of a sudden the system breaks, and then oh, I'm pre-diabetic. And meanwhile, you had triglycerides of 250 six years ago. And well, A1C is fine, so you're doing fine. Anyway, I think that's good. I mean, so much more I have in my notes here, but um that's more than enough.

SPEAKER_03:

That was great. What was your favorite meal of the weekend?

SPEAKER_01:

Oh, I had uh I we were at the JW Marriott at the Mall of America Saturday night. I went after my workout at the hotel, I went and got a salad there that was grown in an organic hydropionic garden on site.

SPEAKER_03:

Fancy.

SPEAKER_01:

Yep. And then I got like an Amish chicken afterward.

SPEAKER_03:

Is that like one of those little chickens?

SPEAKER_01:

That's a Cornish game hen.

SPEAKER_03:

Oh, thank you.

SPEAKER_01:

Yeah, I don't know. It said Amish chicken. Yeah. But no, it was uh you always eat well at these things, and yeah, it was great. You know, it's a long weekend. Uh see patients Friday morning, run to the airport, Friday, all day Saturday, all day Sunday, got in around 11 o'clock Sunday night, turned right around, saw patients Monday. So definitely exhausted from it, but so inspired.

SPEAKER_02:

For more about what we do at the facility, check out our website www.thefacilitydenver.com. You can also follow us on Instagram at the facility Denver for extra tips, behind the scenes fun, and updates on new episodes. Thanks for listening now. Go facilitate your own health, and we'll see you next time.